Potential Role of the Chemokine Macrophage Inflammatory Protein 1 in Human and Experimental Schistosomiasis

نویسندگان

  • Adriano L. S. Souza
  • Ester Roffê
  • Vanessa Pinho
  • Danielle G. Souza
  • Adriana F. Silva
  • Remo C. Russo
  • Rodrigo Guabiraba
  • Cı́ntia A. J. Pereira
  • Flávia M. Carvalho
  • Michele M. Barsante
  • Rodrigo Correa-Oliveira
  • Lúcia A. O. Fraga
  • Deborah Negrão-Correa
  • Mauro M. Teixeira
چکیده

Potential Role of the Chemokine Macrophage Inflammatory Protein 1 in Human and Experimental Schistosomiasis Adriano L. S. Souza, Ester Roffê, Vanessa Pinho, Danielle G. Souza, Adriana F. Silva, Remo C. Russo, Rodrigo Guabiraba, Cı́ntia A. J. Pereira, Flávia M. Carvalho, Michele M. Barsante, Rodrigo Correa-Oliveira, Lúcia A. O. Fraga, Deborah Negrão-Correa, and Mauro M. Teixeira* Laboratório de Imunofarmacologia, Departamento de Bioqu¡mica e Imunologia, and Grupo Interdisciplinar de Estudos em Esquistossomose, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, and Laboratório de Imunologia Celular, Centro de Pesquisa René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, and Laboratório de Imunologia, Universidade do Vale do Rio Doce, Montes Claros, Brazil

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Potential role of the chemokine macrophage inflammatory protein 1alpha in human and experimental schistosomiasis.

In human schistosomiasis, the concentrations of the chemokine macrophage inflammatory protein 1alpha (MIP-1alpha/CCL3) is greater in the plasma of patients with clinical hepatosplenic disease. The objective of the present study was to confirm the ability of CCL3 to detect severe disease in patients classified by ultrasonography (US) and to evaluate the potential role of CCL3 in Schistosoma mans...

متن کامل

Plasma concentrations and role of macrophage inflammatory protein-1alpha during chronic Schistosoma mansoni infection in humans.

Chemokines play an important role during granulomatous inflammation in murine models of Schistosoma mansoni infection. Here, the expression and possible roles of chemokines during human S. mansoni infection were examined. Compared with uninfected individuals, infected patients had elevated plasma concentrations of macrophage inflammatory protein (MIP)-1alpha, RANTES (regulated on activation, no...

متن کامل

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

Dendritic cells initiate immune responses by ferrying antigen from the tissues to the lymphoid organs for presentation to lymphocytes. Little is known about the molecular mechanisms underlying this migratory behavior. We have identified a chemokine receptor which appears to be selectively expressed in human dendritic cells derived from CD34+ cord blood precursors, but not in dendritic cells der...

متن کامل

In Vivo Inhibition of CC and CX3C Chemokine–induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II

Chemokines play a central role in immune and inflammatory responses. It has been observed recently that certain viruses have evolved molecular piracy and mimicry mechanisms by encoding and synthesizing proteins that interfere with the normal host defense response. One such viral protein, vMIP-II, encoded by human herpesvirus 8, has been identified with in vitro antagonistic activities against C...

متن کامل

Comparative Analysis of Expression of Chemokoine Receptors CXCR4, CXCR6, CCR1 and CX3CR in Human Adipose-Drived Mesenchymal Stem Cell with Valproic Acid

Introduction: Chemokine receptors are found on the surface of stem cells. There have been 19 distinct chemokine receptors described in mammals. Chemokines are major players in migration and homing. Therefore, changes in their levels or function can help us to increase the migratory potential of these cells. Valproic acid differs in structure from other drugs in common use. The way in which Va...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005